Hypoglycemic and Hypolipidemic Activity of Plant Extracts
Medicinal plants have become a major source of safe and effective hypoglycemic and hypolipidemic drugs in several countries. Functional ingredients obtained from these medicinal plant extracts for hypoglycemic and hypolipidemic properties are considered to be less toxic or free of side effects compared to synthetic products. Lifeasible can assist you in obtaining extracts from your target plant species and evaluating them for hypoglycemic and hypolipidemic activity through metric evaluation.
Our Services for Hypoglycemic and Hypolipidemic Activity Study
Preparation Method and Process of Extract (slightly different from different materials, for reference only)
- Selected plant raw materials, through several processes to obtain the extract.
- Chromatographed on a large pore adsorbent resin column.
- Separate the different polar parts.
Indicators and System for Evaluating The Hypoglycemic and Hypolipidemic Activities of The Extracts
- α-amylase activity inhibition system
- α-glucosidase activity inhibition system
- Pancreatic lipase activity inhibition system
- Cholesterol esterase reaction system
- Cholesterol micelle solubility reaction system
In the in vitro study on the inhibition rate of functional factors on digestive enzymes and cholesterol micellar solubility, we used the inhibitory effect of the inhibitor on pancreatic lipase, α-amylase, α-glucosidase, cholesterol esterase, and cholesterol micellar solubility as an evaluation criterion. We can compare the IC50 values of functional factors on the solubility of pancreatic lipase, α-amylase, α-glucosidase, cholesterol esterase, and cholesterol micelles.
- Orthogonal t-value method-primary drug analysis
We screened by functional factor and identified primary and secondary drugs based on the data.
- Auxiliary drug interactions
We used orthogonal t-values and weighted composite analysis to analyze the interactions between the adjuvants and the main drug. The inhibitory effect of functional factors on α-amylase and cholesterol esterase activities was used as the assay.
- D-value optimization method of dose proportioning
We used the IC50 of each functional factor on α-amylase, α-glucosidase, and cholesterol esterase as the basis for dosage selection, and calculated the inhibition rate of different dose ratios of the functional factors on α-amylase, α-glucosidase, and cholesterol esterase. The larger the value, the better the dosing effect, thus enabling us to select the optimal dosage.
Lifeasible uses aqueous extraction combined with modern separation techniques to extract, concentrate, and dry the target materials, from which different polar extracts are obtained. Their hypoglycemic and hypolipidemic activities are tested and evaluated. Our services can be used for the development and utilization of health food, functional food, new resource food, and other fields.
Please feel free to contact us to submit your research requirements; we will provide customized solutions as quickly as possible.
※ For research or industrial raw materials, not for personal medical use!