Antitumor Research

Anti-tumor drug research has shifted from traditional cytotoxic drugs to novel anti-tumor drugs with multi-site and multi-target actions against specific mechanisms. Anti-tumor drugs include synthetic chemical drugs and natural drug extracts, which are characterized by low adverse effects, unique actions, and low research costs. Lifeasible helps you research the anti-tumor mechanism of plant extracts and actively promotes their application as anti-tumor drugs or anti-tumor adjuvants.

Our Services for Antitumor Research

Cancer cells divide more frequently than normal cells, and microtubules play an important role in mitosis. Sea urchin embryos were used to mimic vigorously dividing tumor cells that depend on microtubule protein kinetics.

• We added a test substance to the aqueous medium containing the embryos and determined the concentration at which the rate of division changed and at which division ceased completely. The lower the concentration, the greater the anti-mitotic activity of the substance. When cell division was interrupted by the potent anti-microtubulin activity of a drug, the embryos of sea urchins began to rotate axially. Using an ordinary light microscope, we can easily and conveniently observe this effect.
• Using the embryos, we were able to determine several important parameters necessary for an anticancer molecule, including specific anti-mitotic effects, solubility, overall toxicity, and biofilm permeability.

In addition to this, plant extract-mediated silver nanoparticles (AgNPs) have been widely explored for various antitumor therapeutic applications.

• Preparation of plant extracts
• Synthesis of AgNPs
• Perform characterization

For different characteristics and properties of AgNPs such as shape, size, surface charge, crystallinity, surface coating, and biological activity, we can use various analytical techniques to determine them. Examples include ultraviolet-visible spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and dynamic light scattering (DLS).

Figure 1. The phytocomponent conjugated silver nanoparticles (AgNPs) have been extensively explored for various therapeutic applications. (Mahak, M., et al., 2022)

The anti-tumor mechanisms of plant extracts act at multiple levels, in multiple segments, at multiple target sites, and in multiple signaling pathways. One plant extract has multiple mechanisms, or multiple plant extracts can interact with one mechanism. Botanical extracts have a wide range of actions and low adverse effects. Combined with chemotherapy and radiotherapy, they have a detoxifying and sensitizing effect, as well as reducing the damage to the body caused by surgery and alleviating the immunosuppression and inflammatory response caused by chemotherapy in tumor patients. Lifeasible offers services to help you elucidate the molecular mechanisms and targets of these plant extracts.

Please feel free to contact us with the target extracts for your study so that we can develop a protocol for you as soon as possible.

※ For research or industrial raw materials, not for personal medical use!