Anti-inflammatory Mechanism

Inflammation is associated with many diseases, and chronic inflammation, or inflammation that persists over a long period, can cause damage and lead to disease. As anti-inflammatory substances, natural and synthetic corticosteroid preparations produce many side effects, while plant extracts act as anti-inflammatory agents, mitigating the harmful side effects of medications, modulating the composition of the gut microbiota, and obtaining significantly improved anti-inflammatory effects. Lifeasible can provide you with different animal models of inflammation to evaluate the anti-inflammatory effects of plant extract samples.

Our Services for Anti-inflammatory Mechanism Study

Inflammation generally goes through three phases: early, middle, and late. The early phase is also referred to as the vascular response, the middle phase as the cellular response, and the late phase as the tissue response. Blocking any of these phases of the inflammatory process can have an anti-inflammatory effect. In the study of anti-inflammatory mechanisms of plant extracts, we provide you with inflammation models designed according to the nature of these three different phases of inflammation, including the exudation and swelling model, leukocyte wandering model, and granulomatous hyperplasia model.

Examples of inflammatory factor tracer mouse models

We can construct a series of mouse models of interleukin gene promoter-driven reporter gene expression by inserting luciferase and GFP fusion reporter genes into the interleukin gene transcription start site using a knock-in approach. These mouse models have a deletion of a specific interleukin gene expression in a pureblooded individual, while this endogenous promoter drives the reporter gene expression. The intensity of reporter gene expression reflects the degree of activation of a specific inflammatory factor, thus allowing the customer to track inflammatory factors in vivo in real-time and visualize the pattern of inflammatory factor expression.

We offer animal models that can be used to study the anti-inflammatory effects of plant extracts:

With the wide range of animal models of inflammation available from Lifeasible, you can visually quantify the anti-inflammatory effects of your target plant extracts to find the optimal formulations faster and make timely adjustments to existing combinations. Please feel free to contact us for detailed information.

※ For research or industrial raw materials, not for personal medical use!