Chronic Toxicity Assessment
Plant extracts are widely used in animal husbandry, healthcare, the food industry, the cosmetic industry, and many other fields. Chronic toxicity test is the third stage in the toxicological safety evaluation of plant extracts, which aims to observe the toxicological properties and target organs of animals after long-term exposure to different dose levels.
During the project, Lifeasible can comprehensively evaluate the chronic toxicity intensity of the tested plant extracts by recording the animal's symptoms, growth condition, food consumption, blood routine indexes, blood biochemical indexes, urinalysis, pathological and histological observations, etc. The maximum non-effective dose (MNED) can be preliminarily determined, which can provide a basis for determining the dose of chronic toxicity test and preliminarily calculating the safe level of population exposure.
Our Services
- 90 d feeding test service
- Tracking body mass, organ mass, and food intake
- Detecting blood for routine blood tests and biochemical indicators
- Dissection of animals for pathological histological examination
We offer a 90 d feeding test to determine the toxic effects induced by repeated oral exposure to a test plant extract throughout 90 d, to understand the dose-response relationship, the target organ of toxicity, and the reversibility of the effects of the plant extract. The least observed adverse effect level (LOAEL) and no observed adverse effect level (NOAEL) can be derived for 90 d oral exposure. This provides a preliminary determination of the oral safety of the tested plant extracts and provides a basis for the selection of chronic toxicity test doses, LOAELs, and toxicity endpoints, and for obtaining tentative human health guideline values.
- Accumulative toxicity test service
We use a dose-escalation accumulation factor method, using mice as indicator organisms, to calculate the accumulation toxicity dose of a plant extract based on the results of an acute oral toxicity test. We can determine the accumulation strength based on the calculated accumulation factor.
- Chronic inhalation toxicity testing service
We use a kinetic method to determine the toxic effects induced by repeated respiratory exposure to a test plant extract over a certain period. We provide technical support for determining the concentration of plant extracts for chronic respiratory toxicity tests by identifying the target organ of detoxification, the degree of damage, and the no-effect concentration level.
Why Choose Us?
Toxicological evaluation of plant extracts is an important part of the safety evaluation of plant extracts, and chronic toxicity test is an important part of toxicological evaluation. Lifeasible can reflect the dual indicators of nutrition and toxicology of plant extracts through long-term animal feeding tests, detecting the corresponding specific indicators and comparing them with the control group. This allows us to evaluate the toxicological effects of plant extracts and provide technical support for their further application in various fields. Please feel free to contact us to start your project as soon as possible.
※ For research or industrial raw materials, not for personal medical use!